A new study by PhD student Sara Hijazi (MCN) shows that reducing the activity of interneurons in the hippocampus restores memory and delays Alzheimer’s disease progression in mice. The study is published in Molecular Psychiatry.

A new study by PhD student Martina Rosato (MCN) shows that combined cellular and molecular profiling is able to reveal novel biological insight into the polygenic nature of schizophrenia. The study was published last month in Molecular Psychiatry.

A study performed by PhD students Mariana Matos and Esther Visser in the team of Michel van den Oever reveals that expression of a remote fear memory depends on a small ensemble of neurons in the medial prefrontal that functions as an enduring physical memory trace, or engram.

A team of researchers from the CNCR (led by Priyanka Rao-Ruiz and Michel van den Oever, MCN lab) and the Erasmus MC (led by Steven Kushner, Dept. of Psychiatry) used a sensitive and unbiased RNA sequencing approach to identify gene expression signatures critical to the storage of long-term memories by sparse ensembles of hippocampal neurons. This collaborative effort was published in Nature Communications.

Research team led by Ronald van Kesteren receives 675 k€ to investigate changes in brain activity that can provide new diagnostic markers or treatment targets for early-stage Alzheimer’s disease.