Glial Regulated Neuronal Plasticity

Collaborative work between the teams of Mark Verheijen (VU-MCN) and Aniko Korosi (UvA-SILS), is recently published in Alzheimer’s and Dementia. The research was mainly performed by Mandy Kater (VU) and Janssen Kotah (UvA), among others, and shows that ‘Early-life stress and amyloidosis share pathogenic pathways involving astrocyte lipid metabolism and the synaptic mitochondrial proteome’.

Aina Badia-Soteras, together with others of the Neuron-Glia Interaction team and collaborators, has shown that retraction of fine astrocyte processes from the synapse is a regulated process that gates the strength of fear memories. This work is published in Biological Psychiatry

Mandy Kater, together with collaborators of the Memorable consortium, has shown that prevention of microgliosis halts early memory loss in a mouse model of Alzheimer’s disease. This work is published in Brain Behavior and Immunity

A team effort of Nutabi Camargo, Andrea Goudriaan, Anne-Lieke van Deijk, Mark Verheijen (PI) and collaborators shows that myelination by oligodendrocytes in the CNS requires lipids derived from astrocytes and diet.

Anne-Lieke van Deijk (PhD student) and Mark Verheijen (PI) show for the first time that astrocyte lipid metabolism is essential for synapse development in vivo.